ea0002p82 | Signalling | SFE2001
Pawson A
, Lopes J
, Katz A
, Maudsley S
, Sellar R
, Miller N
, #Y-M|#Sun|#
, Millar R
, Davidson J
The chicken gonadotropin-releasing hormone receptor (cGnRH-R) is notable for having a cytoplasmic carboxyl-terminal tail, which is not present in the mammalian GnRH-Rs. We have previously shown that the cGnRH-R undergoes rapid agonist-induced internalization, and requires the carboxyl-terminal tail for this process. To investigate the role of the carboxyl-terminal tail of the cGnRH-R in relation to its rapid internalization, and to identify the key residues involved, a series ...